BIOACCUMULATIVE POTENTIAL P}MFbN#[>r(y Watch Now. . Cellulose microcrystalline. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. . 130. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Superior Performance: Provides excellent water uptake and rapid swelling . <>
Synonyms: Cellulose, Cellulose powder, Cotton linters. Production of Pharmaceutical Grade Microcrystalline Cellulose. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. The most. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. [FMC Study Number I92-1464]. Battista, O. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. PDF (4.11 mb) Footer menu 1. >>
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Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. Validity Area. High performance lubricant that brings more to the tablet. endobj
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eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Millipore. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Unique functionality for a broad range of pharmaceutical applications. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Alginates also function as actives in some anti-reflux products. 1.3. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Page 1 of 8. Well-recognized product that can do it all. Are you sure you want to delete your template? Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Your file is uploaded and ready to be published. Avicel RC-591 & CL-611 - Description. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e
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'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Learn about FMC's differentiated biologically-based crop solutions. (1962). ChemicalBook. <>
PDF (2.77 mb) 2021 FMC Sustainability Report. Explore how we work and why we apply science and creativity for a better world to everything we do. %
w !1AQaq"2B #3Rbr AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. We respect your privacy FMC Privacy Policy. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Document(s): certificate data msds. Looking for FMC'searnings news? J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA
Cu:3(]N"AQdUt~h|P Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Report Category. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . A., and Smith, P. A. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. SUBSTANCE IDENTIFICATION 1.1. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. %PDF-1.5
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&0Y# : CL-611NF Date Approved: 01/13/2010. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. 2008-2023 ChemPoint. Product Name: Microcrystalline Cellulose 1.2. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. MSDS Ref. endstream
cas:9032-51-3 msds CELLULOSE PAB. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Wu, K. Zuurman, H.W. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Powder becomes slippery when wet. <>
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: 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. 4 0 obj
Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Revision No. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. PharmaCentral 2021 . INCI. Micro Crystalline Cellulose. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1.
!(!0*21/*.-4;K@48G9-.BYBGNPTUT3? GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. stream
( This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. No. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. 51395-75-6 Avicel RC 591. Protect them from sunshine or rain. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
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. Product and Company Identification . SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. <
gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" /Resources 2 0 R
The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Have an order or account question, find answers in our Online Support articles. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. The typical mean particle size is 20200 m. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Chemical Formula: (C6H10O5)n 1.4. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Combines good flow and high compactibility. Eur., JPE . Hi, let us know if you have any questions as you visit our website. Fiber supplements can lessen the absorption of some . Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . CAS #: 9004-34-6 1.6. MATERIAL SAFETY DATA SHEET. CAS #: 9004-34-6 . cas:9000-11-7 msds Carboxymethyl cellulose. These, in turn, are assembled into fibrils in the cell wall.